Revolution Medicines, Inc., a clinical-stage precision oncology company, focuses on developing therapies to inhibit frontier targets in RAS-addicted cancers. The company is developing RMC-4630, an inhibitor of SHP2, which is in Phase 1/2 clinical trial for the treatment of solid tumors, such as gynecologic and colorectal cancer tumors. It also develops RMC-5845, a selective inhibitor of SOS1, a protein that converts RAS (OFF) to RAS (ON) in cells; and RMC-5552, a hyperactivated selective inhibitor of mTORC1 signaling in tumors. In addition, the company is developing RMC-6291, a mutant-selective inhibitor of KRASG12C(ON) and NRASG12C(ON); and RMC-6236, a RAS-selective inhibitor of multiple RAS(ON) variants. Further, it develops RAS(ON) Inhibitors targeting KRASG13C(ON) and KRASG12D(ON). The company has a collaboration agreement with Sanofi for the research and development of SHP2 inhibitors, including RMC-4630. Revolution Medicines, Inc. was incorporated in 2014 and is headquartered in Redwood City, California.
Over the last 12 months, insiders at Revolution Medicines, Inc. have bought $0 and sold $12.88M worth of Revolution Medicines, Inc. stock.
On average, over the past 5 years, insiders at Revolution Medicines, Inc. have bought $20.77M and sold $105.4M worth of stock each year.
There was no buying activity among insiders over the last 12 months.
The last purchase of 100,000 shares for transaction amount of $2.05M was made by Schroeder Thilo (director) on 2023‑03‑10.
2024-06-25 | Sale | Kelsey Stephen Michael | See Remarks | 16,467 0.01% | $39.06 | $643,152 | -1.63% | |
2024-06-24 | Sale | Kelsey Stephen Michael | See Remarks | 200 0.0001% | $39.00 | $7,800 | +0.86% | |
2024-06-17 | Sale | GOLDSMITH MARK A | See Remarks | 11,950 0.0069% | $37.39 | $446,770 | +2.99% | |
2024-06-17 | Sale | Kelsey Stephen Michael | See Remarks | 3,349 0.0019% | $37.39 | $125,209 | +2.99% | |
2024-06-17 | Sale | Horn Margaret A | Chief Operating Officer | 4,415 0.0026% | $37.39 | $165,064 | +2.99% | |
2024-06-17 | Sale | Anders Jack | Chief Financial Officer | 1,893 0.0011% | $37.39 | $70,775 | +2.99% | |
2024-06-17 | Sale | Wei Lin | Chief Medical Officer | 5,589 0.0032% | $37.39 | $208,954 | +2.99% | |
2024-06-17 | Sale | Cislini Jeff | General Counsel | 1,757 0.001% | $37.39 | $65,690 | +2.99% | |
2024-06-03 | Sale | GOLDSMITH MARK A | See Remarks | 7,500 0.0045% | $39.99 | $299,942 | -2.89% | |
2024-05-21 | Sale | Cislini Jeff | General Counsel | 1,500 0.0009% | $39.11 | $58,671 | -2.74% | |
2024-05-03 | Sale | Anders Jack | Chief Financial Officer | 10,000 0.0058% | $40.03 | $400,260 | -3.41% | |
2024-04-10 | Sale | GOLDSMITH MARK A | See Remarks | 17,500 0.0103% | $35.40 | $619,467 | +4.63% | |
2024-04-10 | Sale | Patel Sushil | director | 2,155 0.0013% | $37.00 | $79,735 | +4.63% | |
2024-03-27 | Sale | Cislini Jeff | General Counsel | 1,500 0.0009% | $30.99 | $46,481 | +18.92% | |
2024-03-18 | Sale | GOLDSMITH MARK A | See Remarks | 5,788 0.0036% | $31.58 | $182,804 | +20.99% | |
2024-03-18 | Sale | Kelsey Stephen Michael | See Remarks | 2,123 0.0013% | $31.58 | $67,051 | +20.99% | |
2024-03-18 | Sale | Horn Margaret A | Chief Operating Officer | 2,914 0.0018% | $31.58 | $92,033 | +20.99% | |
2024-03-18 | Sale | Anders Jack | Chief Financial Officer | 1,261 0.0008% | $31.58 | $39,826 | +20.99% | |
2024-03-18 | Sale | Cislini Jeff | General Counsel | 1,252 0.0008% | $31.58 | $39,542 | +20.99% | |
2024-03-12 | Sale | Horn Margaret A | Chief Operating Officer | 7,936 0.0049% | $34.07 | $270,345 | +11.22% |
GOLDSMITH MARK A | See Remarks | 311885 0.2297% | $38.42 | 0 | 31 | |
Kelsey Stephen Michael | See Remarks | 269073 0.1353% | $38.42 | 0 | 38 | |
Horn Margaret A | Chief Operating Officer | 136651 0.0619% | $38.42 | 0 | 26 | |
Anders Jack | Chief Financial Officer | 101176 0.0467% | $38.42 | 0 | 16 | |
Wei Lin | Chief Medical Officer | 70851 0.0429% | $38.42 | 0 | 1 | |
Cislini Jeff | General Counsel | 51487 0.0221% | $38.42 | 0 | 11 | |
Weber Barbara | director | 15825 0.0097% | $38.42 | 0 | 9 | |
Patel Sushil | director | 15700 0.0095% | $38.42 | 0 | 1 | |
TEPPER ROBERT I | 5104130 3.1161% | $38.42 | 0 | 1 | ||
COLUMN GROUP III, LP | 10 percent owner | 2151026 1.3132% | $38.42 | 0 | 1 | |
Svennilson Peter | director | 1571963 0.9597% | $38.42 | 0 | 9 | |
Schroeder Thilo | director | 1553134 0.9482% | $38.42 | 14 | 0 | +9.37% |
Flynn James E | 10 percent owner | 1297589 0.7922% | $38.42 | 1 | 0 | +14.18% |
Kim Lorence H. | 60500 0.0369% | $38.42 | 1 | 0 | +5.12% | |
Wang Xiaolin | See Remarks | 58813 0.0359% | $38.42 | 0 | 7 | |
ANDERSON ELIZABETH M | director | 26990 0.0165% | $38.42 | 0 | 3 | |
Miller Vincent A. | director | 20133 0.0123% | $38.42 | 0 | 5 | |
Exter Neil | 0 0% | $38.42 | 0 | 3 | ||
Third Rock Ventures II, L.P. | 10 percent owner | 0 0% | $38.42 | 0 | 4 |
The Vanguard Group | $475.62M | 8.94 | 14.76M | +0.84% | +$3.96M | 0.01 | |
Wellington Management Company | $474.26M | 8.92 | 14.71M | -1.13% | -$5.39M | 0.08 | |
BlackRock | $396.69M | 7.46 | 12.31M | -4.99% | -$20.83M | 0.01 | |
Baker Bros Advisors LP | $243.31M | 4.58 | 7.55M | +46.63% | +$77.37M | 3.06 | |
Farallon Capital | $241.98M | 4.55 | 7.51M | +11.45% | +$24.85M | 1.69 | |
Nextech Invest | $202.94M | 3.82 | 6.3M | 0% | +$0 | 33.09 | |
Bvf Inc Il | $192.77M | 3.63 | 5.98M | 0% | +$0 | 1.42 | |
Casdin Capital | $181.06M | 3.41 | 5.62M | -1.7% | -$3.13M | 13.47 | |
State Street | $173.59M | 3.27 | 5.39M | -13.87% | -$27.95M | 0.01 | |
Alphabet | $170.87M | 3.21 | 5.3M | 0% | +$0 | 6.81 | |
Bellevue Group | $163.52M | 3.08 | 5.07M | -0.34% | -$560,802.00 | 2.5 | |
T. Rowe Price | $155.17M | 2.92 | 4.81M | +3.84% | +$5.74M | 0.02 | |
Boxer Capital, LLC | $137.93M | 2.59 | 4.28M | 0% | +$0 | 6.9 | |
Fidelity Investments | $134.29M | 2.53 | 4.17M | +0.06% | +$84,281.45 | 0.01 | |
Janus Henderson | $126.07M | 2.37 | 3.91M | +77.87% | +$55.19M | 0.07 | |
Woodline Partners LP | $122.38M | 2.3 | 3.8M | +28.28% | +$26.98M | 1.16 | |
JPMorgan Chase | $113.1M | 2.13 | 3.51M | -20.1% | -$28.44M | 0.01 | |
Deerfield Management | $99.59M | 1.87 | 3.09M | 0% | +$0 | 1.93 | |
Geode Capital Management | $98.4M | 1.85 | 3.05M | +2.48% | +$2.38M | 0.01 | |
Paradigm BioCapital Advisors LP | $93.95M | 1.77 | 2.91M | New | +$93.95M | 3.41 | |
Holocene Advisors, LP | $78.07M | 1.47 | 2.42M | -15.95% | -$14.82M | 0.29 | |
Ameriprise Financial | $54.61M | 1.03 | 1.69M | +4.4% | +$2.3M | 0.02 | |
Balyasny Asset Management Llc | $53.34M | 1 | 1.65M | +191.81% | +$35.06M | 0.14 | |
Marshall Wace | $49.5M | 0.93 | 1.54M | +27.05% | +$10.54M | 0.06 | |
Dimensional Fund Advisors | $42.91M | 0.81 | 1.33M | -25.85% | -$14.96M | 0.01 | |
Artal Group S A | $42.5M | 0.8 | 1.32M | -22.25% | -$12.16M | 0.23 | |
Northern Trust | $39.14M | 0.74 | 1.21M | -4.45% | -$1.82M | 0.01 | |
Goldman Sachs | $36.21M | 0.68 | 1.12M | +6.66% | +$2.26M | 0.01 | |
Charles Schwab | $33.91M | 0.64 | 1.05M | +0.89% | +$299,610.08 | 0.01 | |
Frazier Life Sciences Management L P | $32.15M | 0.61 | 997,455 | 0% | +$0 | 1.65 | |
Morgan Stanley | $29.88M | 0.56 | 927,070 | -43.92% | -$23.4M | <0.01 | |
ROCK SPRINGS CAPITAL MANAGEMENT, LP | $29.77M | 0.56 | 923,681 | +27.38% | +$6.4M | 0.76 | |
Soleus Capital Management, L.P. | $23.49M | 0.44 | 728,700 | +189.17% | +$15.36M | 0.22 | |
FINEPOINT CAPITAL LP | $21.82M | 0.41 | 677,100 | +9.72% | +$1.93M | 3.96 | |
Avidity Partners Management Lp | $20.47M | 0.39 | 635,000 | +958.33% | +$18.53M | 0.74 | |
Perceptive Advisors | $19.95M | 0.38 | 618,885 | -24.42% | -$6.45M | 0.01 | |
Victory Capital Management Inc | $19.36M | 0.36 | 600,581 | +7.56% | +$1.36M | 0.02 | |
Citadel Advisors LLC | $18.95M | 0.36 | 588,088 | -34.95% | -$10.18M | 0.01 | |
Candriam S C A | $18.82M | 0.35 | 583,950 | -3.79% | -$741,289.98 | 0.12 | |
Bank of America | $17.54M | 0.33 | 544,086 | +121.17% | +$9.61M | <0.01 | |
BNY Mellon | $17.06M | 0.32 | 529,409 | -8.91% | -$1.67M | <0.01 | |
DAFNA Capital Management, LLC | $16.5M | 0.31 | 511,894 | 0% | +$0 | 3.84 | |
Mic Capital Management Uk Llp | $16.39M | 0.31 | 508,569 | 0% | +$0 | 3.11 | |
Integral Health Asset Management Llc | $13.54M | 0.26 | 420,000 | +110% | +$7.09M | 1.34 | |
Nuveen | $12.05M | 0.23 | 373,775 | -2.83% | -$351,081.41 | <0.01 | |
Eventide Asset Management | $11.64M | 0.22 | 361,000 | 0% | +$0 | 0.18 | |
Mass General Brigham Inc | $10.9M | 0.21 | 338,191 | New | +$10.9M | 19.08 | |
AllianceBernstein | $10.42M | 0.2 | 323,364 | +0.97% | +$100,525.37 | <0.01 | |
UBS | $9.83M | 0.19 | 304,979 | -0.52% | -$50,891.17 | <0.01 | |
Great Lakes Advisors® | $9.31M | 0.18 | 288,820 | New | +$9.31M | 0.08 |