| 2021-01-26 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 28,333 0.0205% | $63.74 | $1.81M | -40.59% | |
| 2021-01-22 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 40,000 0.0284% | $61.67 | $2.47M | -39.71% | |
| 2021-01-21 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 35,000 0.0248% | $61.20 | $2.14M | -39.2% | |
| 2020-12-17 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 1,407 0.001% | $50.50 | $71,054 | -25.36% | |
| 2020-12-15 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 39,000 0.0269% | $49.77 | $1.94M | -25.54% | |
| 2020-12-07 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 11,000 0.0081% | $51.67 | $568,351 | -22.83% | |
| 2020-11-25 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 12,990 0.0092% | $50.05 | $650,150 | -22.09% | |
| 2020-11-24 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 2,590 0.0019% | $50.83 | $131,650 | -21.66% | |
| 2020-11-23 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 12,100 0.0086% | $50.11 | $606,276 | -21.85% | |
| 2020-09-22 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 50,000 0.0355% | $50.41 | $2.52M | -11.02% | |
| 2020-09-21 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 2,000 0.0014% | $50.18 | $100,360 | -9.41% | |
| 2020-06-25 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 9,914 0.007% | $60.11 | $595,907 | -16.06% | |
| 2020-06-24 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 5,000 0.0036% | $58.80 | $294,000 | -13.23% | |
| 2020-06-19 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 10,000 0.0071% | $58.33 | $583,250 | -12.65% | |
| 2020-06-17 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 17,000 0.0123% | $57.94 | $985,021 | -10.59% | |
| 2020-03-25 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 16,000 0.0115% | $47.00 | $752,000 | +16.12% | |
| 2020-03-19 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 16,000 0.0112% | $45.16 | $722,546 | +17.74% | |
| 2020-03-17 | Sale | Ionis Pharmaceuticals, Inc. IONS | Exec Chairman of the Board | 20,000 0.0144% | $44.75 | $895,000 | +21.9% | |
| 2019-08-21 | Sale | Ionis Pharmaceuticals, Inc. IONS | Chairman and CEO | 10,000 0.0071% | $72.15 | $721,500 | -18.72% | |
| 2019-08-20 | Sale | Ionis Pharmaceuticals, Inc. IONS | Chairman and CEO | 12,000 0.0085% | $71.00 | $852,000 | -17.29% |