| $385M | ||
| $350M | ||
| $215M | ||
| $88M | ||
| $82M | ||
| $62M |
Buys | $0 | 0 | 0 |
Sells | $504,976 | 9 | 100 |
| Mahadevia Ankit | director | 0 | $0 | 1 | $12,947 | $-12,947 |
| Keutzer Timothy | Chief Operating Officer | 0 | $0 | 5 | $148,532 | $-148,532 |
| Rajavelu Esther | See Remarks | 0 | $0 | 3 | $343,496 | $-343,496 |
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct acting IV-administered agent to treat MDR Gram-negative bacterial infections in the hospital; and SPR720, an oral antibiotic for the treatment of non-tuberculous mycobacterial pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; license agreement with Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; collaboration agreement with Bill & Melinda Gates Medical Research Institute to develop SPR720 for the treatment of lung infections caused by Mycobacterium tuberculosis; and license agreement with Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. The company was founded in 2013 and is headquartered in Cambridge, Massachusetts.
Over the last 12 months, insiders at Spero Therapeutics, Inc. have bought $0 and sold $504,976 worth of Spero Therapeutics, Inc. stock.
On average, over the past 5 years, insiders at Spero Therapeutics, Inc. have bought $11.07M and sold $283,400 worth of stock each year.
There was no buying activity among insiders over the last 12 months.
The last purchase of 39,727 shares for transaction amount of $207,971 was made by Aquilo Capital, L.P. () on 2022‑04‑26.
| 2026-02-06 | Sale | Rajavelu Esther | See Remarks | 87,917 0.1522% | $2.36 | $207,484 | +1.40% | |
| 2026-02-06 | Sale | Keutzer Timothy | Chief Operating Officer | 18,652 0.0323% | $2.36 | $44,019 | +1.40% | |
| 2026-02-04 | Sale | Keutzer Timothy | Chief Operating Officer | 3,471 0.006% | $2.24 | $7,775 | +5.01% | |
| 2026-02-03 | Sale | Keutzer Timothy | Chief Operating Officer | 24,224 0.043% | $2.14 | $51,839 | +6.58% | |
| 2026-02-02 | Sale | Rajavelu Esther | See Remarks | 18,442 0.0324% | $2.20 | $40,572 | +4.07% | |
| 2026-02-02 | Sale | Keutzer Timothy | Chief Operating Officer | 18,891 0.0332% | $2.20 | $41,560 | +4.07% | |
| 2025-11-07 | Sale | Rajavelu Esther | See Remarks | 40,270 0.0698% | $2.37 | $95,440 | -4.47% | |
| 2025-08-28 | Sale | Keutzer Timothy | Chief Operating Officer | 1,695 0.003% | $1.97 | $3,339 | +16.00% | |
| 2025-08-28 | Sale | Mahadevia Ankit | director | 6,572 0.0115% | $1.97 | $12,947 | +16.00% | |
| 2025-02-05 | Sale | Shukla Sath | CEO & President | 155,333 0.2951% | $0.78 | $121,160 | +152.00% | |
| 2025-02-05 | Sale | Keutzer Timothy | Chief Operating Officer | 56,537 0.1074% | $0.78 | $44,099 | +152.00% | |
| 2025-02-05 | Sale | Rajavelu Esther | CFO & CBO | 20,689 0.0393% | $0.78 | $16,137 | +152.00% | |
| 2025-02-05 | Sale | Mahadevia Ankit | director | 69,219 0.1315% | $0.78 | $53,991 | +152.00% | |
| 2024-11-08 | Sale | Rajavelu Esther | CFO & CBO | 17,245 0.0314% | $1.30 | $22,419 | -12.12% | |
| 2024-11-07 | Sale | Rajavelu Esther | CFO & CBO | 23,351 0.0429% | $1.31 | $30,590 | -11.07% | |
| 2024-08-27 | Sale | Shukla Sath | CEO & President | 2,757 0.005% | $1.35 | $3,722 | -15.58% | |
| 2024-08-27 | Sale | Mahadevia Ankit | director | 5,912 0.0107% | $1.35 | $7,981 | -15.58% | |
| 2024-08-27 | Sale | Keutzer Timothy | Chief Operating Officer | 2,213 0.004% | $1.35 | $2,988 | -15.58% | |
| 2024-08-05 | Sale | Shukla Sath | CEO and President | 17,641 0.0319% | $1.31 | $23,110 | -13.06% | |
| 2024-08-02 | Sale | Shukla Sath | CEO and President | 14,800 0.0276% | $1.32 | $19,536 | -11.45% |
| Rajavelu Esther | See Remarks | 1012091 1.7964% | $2.38M | 0 | 6 | |
| Keutzer Timothy | Chief Operating Officer | 742506 1.3179% | $1.74M | 0 | 10 | |
| Mahadevia Ankit | director | 703294 1.2483% | $1.65M | 0 | 21 | |
| Aquilo Capital, L.P. | 5321231 9.445% | $12.5M | 3 | 0 | ||
| Aquilo Capital Management, LLC | 10 percent owner | 5207796 9.2436% | $12.24M | 21 | 11 | |
| FORMELA JEAN FRANCOIS | director | 2408128 4.2743% | $5.66M | 1 | 0 | <0.0001% |
| GLAXOSMITHKLINE PLC | 10 percent owner | 1934006 3.4328% | $4.54M | 2 | 0 | <0.0001% |
| Goyal Vikas | director | 1854006 3.2908% | $4.36M | 1 | 0 | <0.0001% |
| Shukla Sath | CEO & President | 1736883 3.0829% | $4.08M | 0 | 10 | |
| Breum Casper | director | 1091774 1.9379% | $2.57M | 1 | 0 | <0.0001% |
| HAMED KAMAL | Chief Medical Officer | 788117 1.3989% | $1.85M | 0 | 2 | |
| JOSEPH TAMARA L | Chief Legal Officer | 531615 0.9436% | $1.25M | 0 | 3 | |
| Sendek Joel | Chief Financial Officer | 15181 0.0269% | $35,675.35 | 1 | 1 | <0.0001% |
| Larkin Cristina | Chief Operating Officer | 1500 0.0027% | $3,525.00 | 1 | 2 | <0.0001% |
$48,218,096 | 42 | 0.89% | $124.5M | |
$16,259,194 | 41 | 120.51% | $130.59M | |
$7,147,964 | 34 | 24.77% | $127.51M | |
$47,292,212 | 27 | -28.21% | $162.81M | |
$167,701,902 | 27 | -3.07% | $116.44M | |
$295,092,700 | 21 | -0.27% | $154.57M | |
$448,999,793 | 15 | -19.99% | $146.32M | |
$178,593,887 | 15 | -14.86% | $127.05M | |
$156,530,514 | 13 | 45.71% | $123.07M | |
$15,799,576 | 12 | -39.52% | $126.49M | |
$13,919,584 | 9 | -30.43% | $144.79M | |
$2,762,881 | 8 | -10.76% | $119.99M | |
Spero Therapeutics, Inc. (SPRO) | $22,090,972 | 7 | -3.49% | $132.4M |
$99,355,998 | 7 | -65.74% | $148.4M | |
$299,343 | 6 | -44.75% | $144.88M | |
$20,729,984 | 5 | 51.71% | $141.72M | |
$556,839 | 5 | 13.42% | $130.25M | |
$13,001,183 | 5 | 58.75% | $154.5M | |
$63,731 | 1 | -19.50% | $159.5M |
| Increased Positions | 26 | +46.43% | 10M | +118.19% |
| Decreased Positions | 22 | -39.29% | 2M | -18.29% |
| New Positions | 13 | New | 10M | New |
| Sold Out Positions | 12 | Sold Out | 1M | Sold Out |
| Total Postitions | 60 | +7.14% | 18M | +99.89% |
| Vanguard Group Inc | $4,676.00 | 3.55% | 1.99M | +39,474 | +2.02% | 2025-09-30 |
| Anson Funds Management Lp | $3,768.00 | 2.86% | 1.6M | -11,900 | -0.74% | 2025-09-30 |
| Renaissance Technologies Llc | $3,414.00 | 2.59% | 1.45M | +620,600 | +74.58% | 2025-09-30 |
| Geode Capital Management, Llc | $1,240.00 | 0.94% | 527,477 | +16,778 | +3.29% | 2025-09-30 |
| Blackrock, Inc. | $1,022.00 | 0.78% | 434,768 | 0 | 0% | 2025-09-30 |
| Informed Momentum Co Llc | $664.00 | 0.5% | 282,445 | +43,305 | +18.11% | 2025-09-30 |
| Ionic Capital Management Llc | $491.00 | 0.37% | 208,725 | +58,725 | +39.15% | 2025-09-30 |
| State Street Corp | $449.00 | 0.34% | 190,951 | +37,500 | +24.44% | 2025-09-30 |
| Arrowstreet Capital, Limited Partnership | $354.00 | 0.27% | 150,516 | +150,516 | New | 2025-09-30 |
| Northern Trust Corp | $305.00 | 0.23% | 129,643 | +28,812 | +28.57% | 2025-09-30 |