Spero Therapeutics, Inc. (SPRO) Insider Trading Activity

NASDAQ$2.3499
Market Cap
$132.4M
Sector
Healthcare
Industry
Biotechnology
Rank in Sector
816 of 885
Rank in Industry
469 of 507

SPRO Insider Trading Activity

SPRO Median Price and Trade Amounts History Chart

Statistics of Insider Transactions

Amount of Insider Buys and Sells

Buys
$0
0
0
Sells
$504,976
9
100

Related Transactions

Mahadevia Ankitdirector
0
$0
1
$12,947
$-12,947
Keutzer TimothyChief Operating Officer
0
$0
5
$148,532
$-148,532
Rajavelu EstherSee Remarks
0
$0
3
$343,496
$-343,496

About Spero Therapeutics, Inc.

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct acting IV-administered agent to treat MDR Gram-negative bacterial infections in the hospital; and SPR720, an oral antibiotic for the treatment of non-tuberculous mycobacterial pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; license agreement with Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; collaboration agreement with Bill & Melinda Gates Medical Research Institute to develop SPR720 for the treatment of lung infections caused by Mycobacterium tuberculosis; and license agreement with Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. The company was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Insider Activity of Spero Therapeutics, Inc.

Over the last 12 months, insiders at Spero Therapeutics, Inc. have bought $0 and sold $504,976 worth of Spero Therapeutics, Inc. stock.

On average, over the past 5 years, insiders at Spero Therapeutics, Inc. have bought $11.07M and sold $283,400 worth of stock each year.

There was no buying activity among insiders over the last 12 months.

The last purchase of 39,727 shares for transaction amount of $207,971 was made by Aquilo Capital, L.P. () on 2022‑04‑26.

List of Insider Buy and Sell Transactions, Spero Therapeutics, Inc.

2026-02-06SaleRajavelu EstherSee Remarks
87,917
0.1522%
$2.36
$207,484
+1.40%
2026-02-06SaleKeutzer TimothyChief Operating Officer
18,652
0.0323%
$2.36
$44,019
+1.40%
2026-02-04SaleKeutzer TimothyChief Operating Officer
3,471
0.006%
$2.24
$7,775
+5.01%
2026-02-03SaleKeutzer TimothyChief Operating Officer
24,224
0.043%
$2.14
$51,839
+6.58%
2026-02-02SaleRajavelu EstherSee Remarks
18,442
0.0324%
$2.20
$40,572
+4.07%
2026-02-02SaleKeutzer TimothyChief Operating Officer
18,891
0.0332%
$2.20
$41,560
+4.07%
2025-11-07SaleRajavelu EstherSee Remarks
40,270
0.0698%
$2.37
$95,440
-4.47%
2025-08-28SaleKeutzer TimothyChief Operating Officer
1,695
0.003%
$1.97
$3,339
+16.00%
2025-08-28SaleMahadevia Ankitdirector
6,572
0.0115%
$1.97
$12,947
+16.00%
2025-02-05SaleShukla SathCEO & President
155,333
0.2951%
$0.78
$121,160
+152.00%
2025-02-05SaleKeutzer TimothyChief Operating Officer
56,537
0.1074%
$0.78
$44,099
+152.00%
2025-02-05SaleRajavelu EstherCFO & CBO
20,689
0.0393%
$0.78
$16,137
+152.00%
2025-02-05SaleMahadevia Ankitdirector
69,219
0.1315%
$0.78
$53,991
+152.00%
2024-11-08SaleRajavelu EstherCFO & CBO
17,245
0.0314%
$1.30
$22,419
-12.12%
2024-11-07SaleRajavelu EstherCFO & CBO
23,351
0.0429%
$1.31
$30,590
-11.07%
2024-08-27SaleShukla SathCEO & President
2,757
0.005%
$1.35
$3,722
-15.58%
2024-08-27SaleMahadevia Ankitdirector
5,912
0.0107%
$1.35
$7,981
-15.58%
2024-08-27SaleKeutzer TimothyChief Operating Officer
2,213
0.004%
$1.35
$2,988
-15.58%
2024-08-05SaleShukla SathCEO and President
17,641
0.0319%
$1.31
$23,110
-13.06%
2024-08-02SaleShukla SathCEO and President
14,800
0.0276%
$1.32
$19,536
-11.45%
Total: 97
*Gray background shows transactions not older than one year

Insider Historical Profitability

<0.0001%
Rajavelu EstherSee Remarks
1012091
1.7964%
$2.38M06
Keutzer TimothyChief Operating Officer
742506
1.3179%
$1.74M010
Mahadevia Ankitdirector
703294
1.2483%
$1.65M021
Aquilo Capital, L.P.
5321231
9.445%
$12.5M30
Aquilo Capital Management, LLC10 percent owner
5207796
9.2436%
$12.24M2111
FORMELA JEAN FRANCOISdirector
2408128
4.2743%
$5.66M10
<0.0001%
GLAXOSMITHKLINE PLC10 percent owner
1934006
3.4328%
$4.54M20
<0.0001%
Goyal Vikasdirector
1854006
3.2908%
$4.36M10
<0.0001%
Shukla SathCEO & President
1736883
3.0829%
$4.08M010
Breum Casperdirector
1091774
1.9379%
$2.57M10
<0.0001%
HAMED KAMALChief Medical Officer
788117
1.3989%
$1.85M02
JOSEPH TAMARA LChief Legal Officer
531615
0.9436%
$1.25M03
Sendek JoelChief Financial Officer
15181
0.0269%
$35,675.3511
<0.0001%
Larkin CristinaChief Operating Officer
1500
0.0027%
$3,525.0012
<0.0001%
*Gray background shows insiders who have made transactions during last year

Historical Insider Profitability vs. Competitors

$48,218,096
42
0.89%
$124.5M
$16,259,194
41
120.51%
$130.59M
$7,147,964
34
24.77%
$127.51M
$47,292,212
27
-28.21%
$162.81M
$167,701,902
27
-3.07%
$116.44M
$295,092,700
21
-0.27%
$154.57M
$448,999,793
15
-19.99%
$146.32M
$178,593,887
15
-14.86%
$127.05M
$156,530,514
13
45.71%
$123.07M
$15,799,576
12
-39.52%
$126.49M
$13,919,584
9
-30.43%
$144.79M
$2,762,881
8
-10.76%
$119.99M
Spero Therapeutics, Inc.
(SPRO)
$22,090,972
7
-3.49%
$132.4M
$99,355,998
7
-65.74%
$148.4M
$299,343
6
-44.75%
$144.88M
$20,729,984
5
51.71%
$141.72M
$556,839
5
13.42%
$130.25M
$13,001,183
5
58.75%
$154.5M
$63,731
1
-19.50%
$159.5M

SPRO Institutional Investors: Active Positions

Increased Positions26+46.43%10M+118.19%
Decreased Positions22-39.29%2M-18.29%
New Positions13New10MNew
Sold Out Positions12Sold Out1MSold Out
Total Postitions60+7.14%18M+99.89%

SPRO Ownership Change vs Market

Institutional Investor Ownership

Top Shareholders
Top Buyers
Top Sellers
New Shareholders
Sold-Out Shareholders
Active Shareholders
Vanguard Group Inc$4,676.003.55%1.99M+39,474+2.02%2025-09-30
Anson Funds Management Lp$3,768.002.86%1.6M-11,900-0.74%2025-09-30
Renaissance Technologies Llc$3,414.002.59%1.45M+620,600+74.58%2025-09-30
Geode Capital Management, Llc$1,240.000.94%527,477+16,778+3.29%2025-09-30
Blackrock, Inc.$1,022.000.78%434,76800%2025-09-30
Informed Momentum Co Llc$664.000.5%282,445+43,305+18.11%2025-09-30
Ionic Capital Management Llc$491.000.37%208,725+58,725+39.15%2025-09-30
State Street Corp$449.000.34%190,951+37,500+24.44%2025-09-30
Arrowstreet Capital, Limited Partnership$354.000.27%150,516+150,516New2025-09-30
Northern Trust Corp$305.000.23%129,643+28,812+28.57%2025-09-30

Financial Ratios

Summary
Comparison with Competitors

Price to Earnings

Price/Earnings to Growth

Price to Sales

Price to Book

Price/Free Cash Flow

Analyst Recommendations

Analyst Price Targets

No data is available at this moment.
Prismo does not provide financial advice and does not issue recommendations or offers to buy stock or sell any security.
Information is provided 'as-is' and solely for informational purposes and is not advice. Prismo does not bear any responsibility for any losses or damage that may occur as a result of reliance on this data.