| 2024-02-02 | Sale | Spero Therapeutics, Inc. SPRO | director | 63,795 0.105% | $1.37 | $87,399 | +4.79% | |
| 2023-08-28 | Sale | Spero Therapeutics, Inc. SPRO | director | 9,040 0.0172% | $1.26 | $11,390 | +13.49% | |
| 2023-02-03 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 12,286 0.0223% | $1.81 | $22,238 | -23.68% | |
| 2021-12-27 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 8,000 0.0264% | $14.58 | $116,666 | -86.67% | |
| 2020-11-04 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 14,740 0.056% | $14.43 | $212,670 | +16.65% | |
| 2020-11-03 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 4,274 0.0111% | $10.08 | $43,098 | +13.96% | |
| 2020-10-23 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 40 0.0001% | $10.07 | $403 | +12.62% | |
| 2020-10-14 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 210 0.0008% | $14.25 | $2,993 | +13.52% | |
| 2020-10-13 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 28,734 0.0761% | $10.09 | $289,978 | +10.77% | |
| 2020-09-08 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 1,548 0.0054% | $10.08 | $15,596 | +12.05% | |
| 2020-07-09 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 4,586 0.022% | $14.31 | $65,613 | +3.97% | |
| 2020-07-07 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 1,508 0.0051% | $10.08 | $15,194 | +3.1% | |
| 2020-06-25 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 5,284 0.0263% | $14.25 | $75,301 | +0.83% | |
| 2020-06-24 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 7,760 0.0379% | $14.28 | $110,839 | -1.76% | |
| 2020-06-23 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 16,090 0.0401% | $7.16 | $115,264 | -0.07% | |
| 2020-06-22 | Sale | Spero Therapeutics, Inc. SPRO | CEO and President | 5,226 0.0129% | $7.15 | $37,365 | -1.14% | |
| 2018-07-06 | Sale | Spero Therapeutics, Inc. SPRO | See Remarks | 3,200 0.0191% | $17.65 | $56,495 | -34.81% | |
| 2018-07-05 | Sale | Spero Therapeutics, Inc. SPRO | See Remarks | 6,152 0.0233% | $11.76 | $72,352 | -38.11% |