| $350M | ||
| $172M | ||
| $115M | ||
| $109M | ||
| $107M | ||
| $100M |
Buys | $0 | 0 | 0 |
Sells | $38,494,096 | 23 | 100 |
| Lu Hongbo | director | 0 | $0 | 1 | $228,334 | $-228,334 |
| Waddill William D. | director | 0 | $0 | 1 | $566,038 | $-566,038 |
| Vakiener Victoria | director | 0 | $0 | 1 | $679,491 | $-679,491 |
| OLUKOTUN ADEOYE Y | director | 0 | $0 | 2 | $850,543 | $-850,543 |
| Apel Daniel Joseph | Chief Financial Officer | 0 | $0 | 1 | $934,285 | $-934,285 |
| Ferrari Mauro | director | 0 | $0 | 2 | $1.02M | $-1.02M |
| PERRY MICHAEL S | director | 0 | $0 | 2 | $2M | $-2M |
| O'Brien Patrick | COO | 0 | $0 | 1 | $3.12M | $-3.12M |
| Hamilton James C | Chief Medical Officer | 0 | $0 | 5 | $5.08M | $-5.08M |
| Anzalone Christopher Richard | Chief Executive Officer | 0 | $0 | 7 | $24.01M | $-24.01M |
Arrowhead Pharmaceuticals, Inc., founded in 1989 and based in Pasadena, California, is a biopharmaceutical company dedicated to discovering and advancing innovative treatments for complex and challenging-to-treat diseases within the United States. The company's extensive therapeutic pipeline primarily leverages RNA interference (RNAi) technology. Among its advanced clinical programs are: ARO-AAT, a Phase II therapeutic targeting liver diseases associated with alpha-1 antitrypsin deficiency; ARO-APOC3, which is undergoing both Phase 2b and Phase 3 clinical evaluations for hypertriglyceridemia; ARO-ANG3, currently in Phase 2b development to reduce the production of angiopoietin-like protein 3; and ARO-HIF2, a Phase 1b candidate designed to treat clear cell renal cell carcinoma. Arrowhead also has several compounds in earlier clinical development, including ARO-HSD in Phase 1/2a for other liver diseases, ARO-ENaC in Phase 1/2a, aimed at decreasing the epithelial sodium channel alpha subunit in lung airways, and ARO-C3, also in Phase 1/2a, for complement-mediated diseases. Further expanding its diverse portfolio, the company is actively developing ARO-Lung2 for chronic obstructive pulmonary disorder (COPD), ARO-DUX4 for facioscapulohumeral muscular dystrophy, ARO-XDH for uncontrolled gout, and ARO-COV for COVID-19 and other pulmonary-borne pathogens. Beyond its core internal programs, Arrowhead is involved in the progression of JNJ-3989, a subcutaneously administered RNAi therapeutic for chronic hepatitis B virus infection; Olpasiran, intended to reduce apolipoprotein A production; and ARO-AMG1, which targets genetically validated cardiovascular pathways. Strategic collaborations are integral to Arrowhead's development efforts. The company holds a licensing and research agreement with Janssen Pharmaceuticals, Inc. for the co-development of ARO-JNJ1, ARO-JNJ2, and ARO-JNJ3, all RNAi therapeutics focused on liver-expressed targets. Additionally, Arrowhead has a licensing and research partnership with Takeda Pharmaceuticals U.S.A., Inc. to develop an RNAi therapeutic candidate specifically for liver disease.
Over the last 12 months, insiders at Arrowhead Pharmaceuticals, Inc. have bought $0 and sold $38.49M worth of Arrowhead Pharmaceuticals, Inc. stock.
On average, over the past 5 years, insiders at Arrowhead Pharmaceuticals, Inc. have bought $63,231 and sold $19.36M worth of stock each year.
There was no buying activity among insiders over the last 12 months.
The last purchase of 1,000 shares for transaction amount of $27,500 was made by Lu Hongbo (director) on 2024‑03‑20.
| 2026-08-18 | Sale | PERRY MICHAEL S | director | 11,600 0.0082% | $87.30 | $1.01M | -1.77% | |
| 2026-08-18 | Sale | OLUKOTUN ADEOYE Y | director | 2,000 0.0014% | $86.96 | $173,920 | -1.77% | |
| 2026-05-12 | Sale | Lu Hongbo | director | 2,970 0.0021% | $76.88 | $228,334 | +3.99% | |
| 2026-04-23 | Sale | Hamilton James C | Chief Medical Officer | 10,000 0.0072% | $75.00 | $750,000 | +7.39% | |
| 2026-04-22 | Sale | Apel Daniel Joseph | Chief Financial Officer | 13,095 0.009% | $71.35 | $934,285 | +8.03% | |
| 2026-03-05 | Sale | Hamilton James C | Chief Medical Officer | 10,000 0.0072% | $64.19 | $641,900 | +20.36% | |
| 2026-01-05 | Sale | O'Brien Patrick | COO | 49,493 0.0354% | $63.11 | $3.12M | +14.91% | |
| 2026-01-05 | Sale | Hamilton James C | Chief Medical Officer | 40,164 0.0287% | $63.11 | $2.53M | +14.91% | |
| 2026-01-02 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 13,187 0.0095% | $66.10 | $871,703 | +8.17% | |
| 2025-12-29 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 51,726 0.0369% | $69.13 | $3.58M | +5.05% | |
| 2025-12-26 | Sale | Ferrari Mauro | director | 7,530 0.0054% | $70.00 | $527,100 | +4.18% | |
| 2025-12-22 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 12,586 0.009% | $68.44 | $861,340 | +5.57% | |
| 2025-12-19 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 13,445 0.0097% | $67.66 | $909,683 | +6.65% | |
| 2025-12-19 | Sale | Waddill William D. | director | 8,367 0.006% | $67.65 | $566,038 | +6.65% | |
| 2025-12-19 | Sale | Vakiener Victoria | director | 10,040 0.0072% | $67.68 | $679,491 | +6.65% | |
| 2025-12-19 | Sale | OLUKOTUN ADEOYE Y | director | 10,000 0.0072% | $67.66 | $676,623 | +6.65% | |
| 2025-12-17 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 85,000 0.0608% | $64.04 | $5.44M | +11.96% | |
| 2025-12-16 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 54,298 0.0359% | $62.58 | $3.4M | +11.89% | |
| 2025-12-15 | Sale | Anzalone Christopher Richard | Chief Executive Officer | 130,000 0.0946% | $68.85 | $8.95M | +5.39% | |
| 2025-12-05 | Sale | PERRY MICHAEL S | director | 16,250 0.0117% | $61.03 | $991,738 | +16.62% |
| Anzalone Christopher Richard | Chief Executive Officer | 3792739 2.6926% | $314.23M | 4 | 51 | <0.0001% |
| O'Brien Patrick | COO | 474908 0.3372% | $39.35M | 0 | 14 | |
| Hamilton James C | Chief Medical Officer | 226958 0.1611% | $18.8M | 0 | 21 | |
| Apel Daniel Joseph | Chief Financial Officer | 162905 0.1157% | $13.5M | 0 | 1 | |
| PERRY MICHAEL S | director | 111459 0.0791% | $9.23M | 0 | 7 | |
| Ferrari Mauro | director | 69053 0.049% | $5.72M | 2 | 6 | +71% |
| Waddill William D. | director | 56563 0.0402% | $4.69M | 0 | 10 | |
| Lu Hongbo | director | 52012 0.0369% | $4.31M | 3 | 1 | <0.0001% |
| Vakiener Victoria | director | 35723 0.0254% | $2.96M | 0 | 5 | |
| OLUKOTUN ADEOYE Y | director | 31600 0.0224% | $2.62M | 0 | 7 | |
| GIVEN BRUCE D | Chief Operating Officer | 850730 0.604% | $70.48M | 0 | 19 | |
| Myszkowski Kenneth Allen | Chief Financial Officer | 455433 0.3233% | $37.73M | 1 | 29 | <0.0001% |
| Li Zhen | Snr. VP, Chem and Non-Clin Dev | 201700 0.1432% | $16.71M | 0 | 1 | |
| San Martin Javier | Chief Medical Officer | 198497 0.1409% | $16.45M | 0 | 5 | |
| KNOTT DAVID M | 10 percent owner | 166778 0.1184% | $13.82M | 1 | 3 | <0.0001% |
| Leone Peter Brian | VP, Strategic Bus. Initiatives | 130000 0.0923% | $10.77M | 0 | 1 | |
| Oliver Tracie | Chief Commercial Officer | 127107 0.0902% | $10.53M | 0 | 3 | |
| GIVEN DOUGLAS B | director | 124167 0.0882% | $10.29M | 1 | 21 | <0.0001% |
| Hassard James | Chief Commercial Officer | 105750 0.0751% | $8.76M | 0 | 2 | |
| FRYKMAN EDWARD W | director | 23852 0.0169% | $1.98M | 0 | 1 | |
| McKenney Charles | director | 17220 0.0122% | $1.43M | 1 | 16 | |
| De Backer Marianne | director | 17000 0.0121% | $1.41M | 9 | 2 | +50.28% |
| Kingsley Joseph Theodore III | Interim President & CFO | 12000 0.0085% | $994,200.00 | 2 | 0 | +27.7% |
| Ching Marshall Robert | 10 percent owner | 0 0% | $0 | 0 | 6 | |
| Lewis David L. | Chief Scientific Officer | 0 0% | $0 | 0 | 3 | |
| Bradshaw Curt | Chief Scientific Officer | 0 0% | $0 | 0 | 2 |
$159,914,414 | 243 | 18.52% | $12.19B | |
$273,531,368 | 93 | 38.24% | $12.35B | |
$2,765,836 | 72 | 20.00% | $12.69B | |
$108,876,545 | 67 | 72.81% | $12.72B | |
$98,300,471 | 40 | 0.27% | $15.44B | |
$19,233,721 | 36 | 70.14% | $14.11B | |
$13,655,378 | 35 | 17.13% | $21.1B | |
Arrowhead Pharmaceuticals, Inc. (ARWR) | $1,801,511 | 23 | 18.58% | $11.67B |
$415,090,639 | 19 | -14.04% | $14.19B | |
$1,479,484 | 17 | 50.46% | $11.36B | |
$639,489,927 | 17 | 128.14% | $14B | |
$11,859,102 | 17 | 18.62% | $9.18B | |
$118,094,211 | 15 | 38.32% | $9.46B | |
$9,976,473 | 12 | 29.52% | $9.33B | |
$762,720 | 11 | 52.96% | $9.01B | |
$11,898,979 | 10 | 54.58% | $10.23B | |
$35,908,794 | 10 | 126.31% | $9.53B | |
$948,235 | 8 | 15.54% | $11.29B | |
$41,376,000 | 4 | -12.07% | $8.59B |
| Increased Positions | 248 | +75.15% | 15M | +13.53% |
| Decreased Positions | 145 | -43.94% | 13M | -11.05% |
| New Positions | 123 | New | 6M | New |
| Sold Out Positions | 29 | Sold Out | 872,791 | Sold Out |
| Total Postitions | 433 | +31.21% | 117M | +2.48% |
| Blackrock, Inc. | $1.37M | 14.87% | 20.22M | +799,938 | +4.12% | 2025-09-30 |
| Vanguard Group Inc | $1.09M | 11.79% | 16.04M | +510,798 | +3.29% | 2025-09-30 |
| Avoro Capital Advisors Llc | $738,911.00 | 8.02% | 10.9M | +300,000 | +2.83% | 2025-09-30 |
| State Street Corp | $433,677.00 | 4.7% | 6.4M | +26,308 | +0.41% | 2025-09-30 |
| Fmr Llc | $390,459.00 | 4.24% | 5.76M | +589,520 | +11.4% | 2025-09-30 |
| Slate Path Capital Lp | $337,730.00 | 3.66% | 4.98M | -250,000 | -4.78% | 2025-09-30 |
| Geode Capital Management, Llc | $212,253.00 | 2.3% | 3.13M | +152,537 | +5.12% | 2025-09-30 |
| Siren, L.L.C. | $180,991.00 | 1.96% | 2.67M | 0 | 0% | 2025-09-30 |
| Driehaus Capital Management Llc | $142,318.00 | 1.54% | 2.1M | +2M | New | 2025-09-30 |
| Arrowstreet Capital, Limited Partnership | $141,118.00 | 1.53% | 2.08M | +2M | +3,142.51% | 2025-09-30 |