| $385M | ||
| $350M | ||
| $215M | ||
| $100M | ||
| $88M | ||
| $62M |
Buys | $0 | 0 | 0 |
Sells | $555,085 | 10 | 100 |
| Cavalier Jason | Chief Financial Officer | 0 | $0 | 2 | $8,681 | $-8,681 |
| Palasis Maria | President & CEO | 0 | $0 | 2 | $19,670 | $-19,670 |
| PERCEPTIVE ADVISORS LLC | 10 percent owner | 0 | $0 | 6 | $526,734 | $-526,734 |
Lyra Therapeutics, Inc., a clinical-stage biotechnology company, focuses on the development and commercialization of anti-inflammatory therapies for the treatment of patients with chronic rhinosinusitis. Its technology is designed to deliver medicines directly to the affected tissue for sustained periods with a single administration. The company's product candidates include LYR-210, an anti-inflammatory implantable drug matrix which is in Phase III clinical trial for the treatment of chronic rhinosinusitis (CRS); and LYR-220 for CRS patients who have failed previous medical management and continue to require treatment to manage CRS symptoms. It has a collaboration agreement with LianBio Inflammatory Limited to develop and commercialize LYR-210 in mainland China, Hong Kong, Taiwan, Macau, South Korea, Singapore, and Thailand. The company was formerly known as 480 Biomedical, Inc. and changed its name to Lyra Therapeutics, Inc. in July 2018. Lyra Therapeutics, Inc. was incorporated in 2005 and is headquartered in Watertown, Massachusetts.
Over the last 12 months, insiders at Lyra Therapeutics, Inc. have bought $0 and sold $555,085 worth of Lyra Therapeutics, Inc. stock.
On average, over the past 5 years, insiders at Lyra Therapeutics, Inc. have bought $33.37M and sold $555,085 worth of stock each year.
There was no buying activity among insiders over the last 12 months.
The last purchase of 25,000 shares for transaction amount of $74,095 was made by Waksal Harlan (Executive Chair) on 2023‑11‑10.
| 2026-01-06 | Sale | Palasis Maria | President & CEO | 1,702 0.0777% | $3.36 | $5,726 | -55.65% | |
| 2026-01-06 | Sale | Cavalier Jason | Chief Financial Officer | 769 0.0351% | $3.36 | $2,587 | -55.65% | |
| 2025-11-13 | Sale | PERCEPTIVE ADVISORS LLC | 10 percent owner | 31,810 1.6829% | $3.90 | $124,062 | -44.24% | |
| 2025-11-12 | Sale | PERCEPTIVE ADVISORS LLC | 10 percent owner | 8,745 0.4815% | $4.06 | $35,499 | -43.30% | |
| 2025-11-11 | Sale | PERCEPTIVE ADVISORS LLC | 10 percent owner | 5,320 0.3114% | $4.31 | $22,954 | -47.52% | |
| 2025-11-10 | Sale | PERCEPTIVE ADVISORS LLC | 10 percent owner | 18,502 1.1394% | $4.54 | $83,995 | -48.98% | |
| 2025-11-07 | Sale | PERCEPTIVE ADVISORS LLC | 10 percent owner | 19,739 1.271% | $4.75 | $93,695 | -50.22% | |
| 2025-11-06 | Sale | PERCEPTIVE ADVISORS LLC | 10 percent owner | 32,149 2.2589% | $5.18 | $166,529 | -52.24% | |
| 2025-07-10 | Sale | Palasis Maria | President & CEO | 1,565 0.1892% | $8.91 | $13,944 | -50.33% | |
| 2025-07-10 | Sale | Cavalier Jason | Chief Financial Officer | 684 0.0827% | $8.91 | $6,094 | -50.33% | |
| 2023-11-10 | Waksal Harlan | Executive Chair | 25,000 0.0498% | $2.96 | $74,095 | -87.57% | ||
| 2023-05-31 | PERCEPTIVE ADVISORS LLC | 3.61M 9.5077% | $2.49 | $9M | +49.42% | |||
| 2023-05-31 | NBVM GP, LLC | 10 percent owner | 1.81M 4.6346% | $2.43 | $4.39M | +49.42% | ||
| 2023-05-31 | NBVM GP, LLC | 10 percent owner | 1.2M 3.0898% | $2.43 | $2.92M | +49.42% | ||
| 2023-05-31 | ANDERSON EDWARD T | 1.81M 4.6346% | $2.43 | $4.39M | +49.42% | |||
| 2022-06-10 | MERRIFIELD C ANN | 4,000 0.0119% | $5.05 | $20,200 | -35.30% | |||
| 2022-05-13 | MERRIFIELD C ANN | director | 3,828 0.0112% | $4.83 | $18,486 | -19.36% | ||
| 2022-05-13 | MERRIFIELD C ANN | 328 0.001% | $5.00 | $1,640 | -19.36% | |||
| 2022-04-12 | PERCEPTIVE ADVISORS LLC | 5.92M 11.8975% | $4.22 | $25M | -21.89% | |||
| 2022-04-12 | EDELMAN JOSEPH | 5.92M 11.8975% | $4.22 | $25M | -21.89% |
| Palasis Maria | President & CEO | 1096733 61.7919% | $542,882.84 | 0 | 2 | |
| Cavalier Jason | Chief Financial Officer | 518547 29.2158% | $256,680.77 | 0 | 2 | |
| PERCEPTIVE ADVISORS LLC | 10 percent owner | 14026 0.7902% | $6,942.87 | 4 | 6 | |
| EDELMAN JOSEPH | 7858285 442.7495% | $3.89M | 1 | 0 | ||
| ANDERSON EDWARD T | 2521745 142.0795% | $1.25M | 5 | 2 | ||
| NBVM GP, LLC | 10 percent owner | 2521745 142.0795% | $1.25M | 5 | 2 | |
| North Bridge Venture Management VI, L.P. | 1318133 74.2659% | $652,475.84 | 1 | 0 | ||
| Polaris Venture Management Co. V, L.L.C. | 10 percent owner | 1062259 59.8495% | $525,818.21 | 1 | 1 | |
| Waksal Harlan | Executive Chair | 261966 14.7596% | $129,673.17 | 2 | 0 | |
| Soleus Private Equity GP I, LLC | 10 percent owner | 155000 8.733% | $76,725.00 | 2 | 2 | |
| MERRIFIELD C ANN | 11328 0.6382% | $5,607.36 | 4 | 0 | ||
| snyderman nancy lynn MD | director | 1025 0.0578% | $507.38 | 1 | 0 | <0.0001% |
$1,848,072 | 66 | -14.67% | $2.55M | |
$53,490,060 | 55 | 19.35% | $3.21M | |
$1,138,733 | 28 | -4.94% | $3.41M | |
$374,478 | 22 | -36.36% | $2.49M | |
$8,079,884 | 14 | -43.20% | $2.01M | |
$82,890 | 11 | -16.71% | $1.73M | |
$389,864 | 11 | 12.52% | $2.48M | |
$18,269 | 10 | -21.15% | $2.73M | |
$126,023 | 10 | -66.17% | $1.86M | |
$90,087 | 9 | 20.06% | $4.4M | |
$7,268,979 | 7 | -48.44% | $2.29M | |
$70,828 | 6 | -57.96% | $1.56M | |
$726,438 | 4 | -72.85% | $1.02M | |
$149,778 | 4 | -45.16% | $3.06M | |
$23,454 | 1 | -99.16% | $4,356.00 | |
$37,000 | 1 | 79.42% | $3.33M | |
Lyra Therapeutics, Inc. (LYRA) | $9,963 | 1 | -14.25% | $878,567.00 |
$19,863 | 1 | 144.27% | $849,022.00 | |
$1,049,630 | 1 | -74.91% | $817,868.00 |
| Increased Positions | 9 | +28.13% | 77,552 | +17.29% |
| Decreased Positions | 12 | -37.5% | 283,524 | -63.2% |
| New Positions | 3 | New | 25,583 | New |
| Sold Out Positions | 6 | Sold Out | 278,522 | Sold Out |
| Total Postitions | 29 | -9.38% | 242,640 | -45.91% |