Tenaya Therapeutics, Inc., a biotechnology company, discovers, develops, and delivers therapies for heart disease in the United States. It develops its products through cellular regeneration, gene therapy, and precision medicine platforms. The company is developing TN-201, an adeno-associated virus (AAV)-based gene therapy to address genetic hypertrophic cardiomyopathy (gHCM) caused by haploinsufficient myosin binding protein C3 (MYBPC3) gene mutations; and TN-301, a small molecule inhibitor of histone deacetylase 6 (HDAC6i) for use in heart failure with preserved ejection fraction (HFpEF) and genetic dilated cardiomyopathy (gDCM). It is also developing TN-401, an AAV-based gene therapy that addresses genetic arrhythmogenic right ventricular cardiomyopathy (gARVC) caused by plakophilin 2 (PKP2) gene mutations; an AAV-based gene therapy designed to deliver the dwarf open reading frame (DWORF) gene in the heart for DCM; and Reprogramming program, an AAV-based approach for cardiac regeneration to replace heart cells lost in patients experiencing heart failure due to prior myocardial infarction. The company was incorporated in 2016 and is headquartered in South San Francisco, California.
Over the last 12 months, insiders at Tenaya Therapeutics, Inc. have bought $20M and sold $296,877 worth of Tenaya Therapeutics, Inc. stock.
On average, over the past 5 years, insiders at Tenaya Therapeutics, Inc. have bought $37.23M and sold $155,292 worth of stock each year.
Highest buying activity among insiders over the last 12 months: GOEDDEL DAVID V () — $20M. COLUMN GROUP III GP, LP (10 percent owner) — $10M.
The last purchase of 2,222,222 shares for transaction amount of $10M was made by GOEDDEL DAVID V () on 2024‑02‑12.
2024-03-05 | Sale | Hoey Timothy | Chief Scientific Officer | 3,300 0.0044% | $7.00 | $23,101 | -34.41% | |
2024-02-20 | Sale | Hoey Timothy | Chief Scientific Officer | 6,569 0.0087% | $5.34 | $35,046 | -13.55% | |
2024-02-16 | Sale | Hoey Timothy | Chief Scientific Officer | 4,681 0.0064% | $5.86 | $27,431 | -28.32% | |
2024-02-16 | Sale | Ali Faraz | Chief Executive Officer | 6,358 0.0087% | $5.86 | $37,258 | -28.32% | |
2024-02-16 | Sale | Tingley Whittemore | Chief Medical Officer | 6,500 0.0088% | $5.86 | $38,090 | -28.32% | |
2024-02-16 | Sale | PATTERSON LEONE D | Chief Fin. and Bus. Officer | 5,201 0.0071% | $5.86 | $30,478 | -28.32% | |
2024-02-12 | GOEDDEL DAVID V | 2.22M 2.6767% | $4.50 | $10M | -19.79% | |||
2024-02-12 | COLUMN GROUP III GP, LP | 10 percent owner | 2.22M 2.6767% | $4.50 | $10M | -19.79% | ||
2023-08-29 | Sale | Hoey Timothy | Chief Scientific Officer | 7,243 0.0111% | $4.26 | $30,855 | -11.26% | |
2023-08-16 | Sale | Hoey Timothy | Chief Scientific Officer | 4,007 0.0059% | $3.81 | $15,267 | -2.08% | |
2023-08-16 | Sale | Ali Faraz | Chief Executive Officer | 5,563 0.0083% | $3.81 | $21,195 | -2.08% | |
2023-08-16 | Sale | Tingley Whittemore | Chief Medical Officer | 5,563 0.0083% | $3.81 | $21,195 | -2.08% | |
2023-08-16 | Sale | PATTERSON LEONE D | Chief Fin. and Bus. Officer | 4,452 0.0066% | $3.81 | $16,962 | -2.08% | |
2023-03-10 | GOEDDEL DAVID V | 6,779 0.0092% | $2.60 | $17,596 | +47.13% | |||
2023-03-10 | COLUMN GROUP III GP, LP | 10 percent owner | 6,779 0.0092% | $2.60 | $17,596 | +47.13% | ||
2023-02-08 | GOEDDEL DAVID V | 1.5M 1.9331% | $2.60 | $3.9M | +16.12% | |||
2023-02-08 | COLUMN GROUP III GP, LP | 10 percent owner | 1.5M 1.9331% | $2.60 | $3.9M | +16.12% | ||
2023-01-19 | GOEDDEL DAVID V | director | 69,739 0.0935% | $2.50 | $174,201 | +23.82% | ||
2023-01-19 | COLUMN GROUP III GP, LP | director | 69,739 0.0935% | $2.50 | $174,201 | +23.82% | ||
2023-01-18 | GOEDDEL DAVID V | director | 135,688 0.1854% | $2.52 | $341,432 | +24.70% |
GOEDDEL DAVID V | 13599275 16.7037% | $2.72 | 7 | 0 | +27.92% | |
COLUMN GROUP III GP, LP | 10 percent owner | 13599275 16.7037% | $2.72 | 7 | 0 | +27.92% |
Hoey Timothy | Chief Scientific Officer | 245346 0.3632% | $2.72 | 0 | 6 | |
Ali Faraz | Chief Executive Officer | 113079 0.1754% | $2.72 | 0 | 2 | |
Tingley Whittemore | Chief Medical Officer | 73534 0.1122% | $2.72 | 0 | 2 | |
PATTERSON LEONE D | Chief Fin. and Bus. Officer | 60755 0.0948% | $2.72 | 0 | 2 | |
Casdin Eli | director | 6078860 8.9249% | $2.72 | 2 | 0 | <0.0001% |
Casdin Partners Master Fund, L.P. | 10 percent owner | 3224849 4.7347% | $2.72 | 1 | 0 | <0.0001% |
Srivastava Deepak | director | 372435 0.5468% | $2.72 | 1 | 0 | +31.12% |
Column Group Llc | $49.16M | 11.97 | 9.4M | 0% | +$0 | 37.33 | |
Casdin Capital | $35.21M | 8.57 | 6.73M | +5.51% | +$1.84M | 2.62 | |
RA Capital Management, L.P. | $30.1M | 7.33 | 5.76M | +4.5% | +$1.3M | 0.03 | |
BlackRock | $24.59M | 5.99 | 4.7M | +24.14% | +$4.78M | <0.01 | |
T. Rowe Price | $17.5M | 4.26 | 3.35M | -26.36% | -$6.27M | <0.01 | |
Fidelity Investments | $15.22M | 3.71 | 2.91M | +9.62% | +$1.34M | <0.01 | |
The Vanguard Group | $14.97M | 3.65 | 2.86M | +16.41% | +$2.11M | <0.0001 | |
Octagon Capital Advisors LP | $14.93M | 3.64 | 2.85M | New | +$14.93M | 1.95 | |
Integral Health Asset Management Llc | $11.77M | 2.87 | 2.25M | New | +$11.77M | 1.17 | |
Citadel Advisors LLC | $11.75M | 2.86 | 2.25M | +12.31% | +$1.29M | 0.01 | |
Vr Adviser Llc | $8.14M | 1.98 | 1.56M | New | +$8.14M | 0.4 | |
Geode Capital Management | $5.44M | 1.33 | 1.04M | +11.98% | +$582,071.77 | <0.0001 | |
Euclidean Capital Llc | $5.31M | 1.29 | 1.02M | 0% | +$0 | 0.68 | |
State Street | $5.07M | 1.23 | 969,297 | +5.45% | +$261,892.23 | <0.0001 | |
Alphabet | $4.79M | 1.17 | 915,705 | 0% | +$0 | 0.19 | |
GHOST TREE CAPITAL LLC | $4.05M | 0.99 | 775,000 | New | +$4.05M | 1.32 | |
StepStone Group | $2.42M | 0.59 | 462,163 | 0% | +$0 | 0.52 | |
Adage Capital Partners Gp L L C | $2.09M | 0.51 | 400,000 | New | +$2.09M | <0.01 | |
Northern Trust | $2.08M | 0.51 | 397,661 | +2.05% | +$41,730.17 | <0.0001 | |
Millennium Management LLC | $1.96M | 0.48 | 375,102 | -25.38% | -$667,180.48 | <0.01 | |
Morgan Stanley | $1.65M | 0.4 | 315,889 | +36.16% | +$438,707.97 | <0.0001 | |
Nuveen | $1.5M | 0.37 | 286,805 | +82.87% | +$679,737.80 | <0.0001 | |
Barclays | $1.43M | 0.35 | 274,013 | +312.7% | +$1.09M | <0.01 | |
Bank of America | $1.18M | 0.29 | 225,869 | +51.79% | +$403,066.03 | <0.0001 | |
Gsa Capital Partners Llp | $1.17M | 0.29 | 224,051 | -52.41% | -$1.29M | 0.09 | |
PFM Health Sciences | $1.16M | 0.28 | 222,222 | New | +$1.16M | 0.03 | |
BNY Mellon | $1.11M | 0.27 | 211,494 | +0.03% | +$277.19 | <0.0001 | |
Bridgeway Capital Management | $1.01M | 0.25 | 193,000 | 0% | +$0 | 0.02 | |
Wellington Management Company | $1.01M | 0.25 | 193,221 | New | +$1.01M | <0.0001 | |
Schonfeld Group | $993,700.00 | 0.24 | 190,000 | New | +$993,700.00 | 0.01 | |
Acadian Asset Management | $936,000.00 | 0.23 | 179,132 | -39.17% | -$602,846.66 | <0.01 | |
Jacobs Levy Equity Management | $881,595.00 | 0.22 | 168,565 | +90.79% | +$419,508.78 | <0.01 | |
Charles Schwab | $670,068.00 | 0.16 | 128,120 | +7.18% | +$44,915.27 | <0.0001 | |
Qube Research & Technologies | $665,423.00 | 0.16 | 127,232 | New | +$665,423.00 | <0.01 | |
Soleus Capital Management, L.P. | $639,221.00 | 0.16 | 122,222 | New | +$639,221.00 | 0.01 | |
Two Sigma Advisers LP | $599,881.00 | 0.15 | 114,700 | -20.9% | -$158,469.00 | <0.01 | |
UBS | $576,220.00 | 0.14 | 110,176 | +144.76% | +$340,796.98 | <0.0001 | |
Two Sigma | $566,644.00 | 0.14 | 108,345 | -42.94% | -$426,433.02 | <0.01 | |
Goldman Sachs | $429,446.00 | 0.11 | 82,112 | +10.24% | +$39,889.23 | <0.0001 | |
American Century Investments | $418,233.00 | 0.1 | 79,968 | +90.18% | +$198,321.77 | <0.0001 | |
Dimensional Fund Advisors | $374,364.00 | 0.09 | 71,580 | -29.85% | -$159,279.90 | <0.0001 | |
Highpoint Advisor Group Llc | $301,000.00 | 0.09 | 70,390 | 0% | +$0 | 0.02 | |
RhumbLine Advisers | $369,852.00 | 0.09 | 70,719 | +3.26% | +$11,678.33 | <0.0001 | |
Squarepoint Ops LLC | $339,364.00 | 0.08 | 64,888 | -55.4% | -$421,574.31 | <0.01 | |
Cornercap Investment Counsel Inc | $337,664.00 | 0.08 | 64,563 | -20.54% | -$87,299.03 | 0.05 | |
Renaissance Technologies | $337,000.00 | 0.08 | 64,500 | -86.63% | -$2.18M | <0.01 | |
Jane Street Capital | $317,974.00 | 0.08 | 60,798 | +293.74% | +$237,217.45 | <0.0001 | |
Atticus Wealth Management | $295,558.00 | 0.07 | 56,512 | -18.48% | -$67,006.81 | 0.1 | |
Woodline Partners LP | $292,880.00 | 0.07 | 56,000 | New | +$292,880.00 | <0.01 | |
Susquehanna International Group | $284,789.00 | 0.07 | 54,453 | -35.42% | -$156,220.00 | <0.0001 |