Cyclacel Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops medicines for the treatment of cancer and other proliferative diseases. The company's development programs include fadraciclib, a cyclin dependent kinase Inhibitors (CDK) that is in Phase 1/2 clinical trial for the treatment of solid tumors, as well as in combination with venetoclax to treat relapsed or refractory chronic lymphocytic leukemia; and CYC140, a polo-like kinase inhibitor program, which is in Phase 1/2 clinical trial for the treatment of advanced leukemias and solid tumors. Its development programs also comprise Sapacitabine, a novel nucleoside analog that is orally available prodrug of CNDAC, which is in Phase 1/2 clinical trials to treat acute myeloid leukemia and myelodysplastic syndrome; and seliciclib, a CDK inhibitor that is in Phase 2 investigator-sponsored trials (IST) for Cushing's disease, as well as in Phase 1/2 IST for the treatment for advanced rheumatoid arthritis. The company has a clinical collaboration agreement with the University of Texas MD Anderson Cancer Center to clinically evaluate the safety and efficacy of three cyclacel medicines in patients with hematological malignancies, including chronic lymphocytic leukemias, acute myeloid leukemias, myelodysplastic syndromes, and other advanced leukemias. Cyclacel Pharmaceuticals, Inc. is headquartered in Berkeley Heights, New Jersey.
Over the last 12 months, insiders at Cyclacel Pharmaceuticals, Inc. have bought $26,374 and sold $0 worth of Cyclacel Pharmaceuticals, Inc. stock.
On average, over the past 5 years, insiders at Cyclacel Pharmaceuticals, Inc. have bought $26,374 and sold $0 worth of stock each year.
Highest buying activity among insiders over the last 12 months: Rombotis Spiro George (President and CEO) — $20,122. McBarron Paul (See Remarks) — $6,252.
The last purchase of 6,070 shares for transaction amount of $20,122 was made by Rombotis Spiro George (President and CEO) on 2023‑12‑21.
2023-12-21 | Rombotis Spiro George | President and CEO | 6,070 0.6595% | $3.31 | $20,122 | -38.33% | ||
2023-12-21 | McBarron Paul | See Remarks | 1,886 0.2049% | $3.31 | $6,252 | -38.33% | ||
2017-02-23 | TANG KEVIN C | 10 percent owner | 134,200 3.3648% | $4.34 | $582,079 | -53.33% | ||
2014-11-20 | BARKER SAM L | director | 3,100 0.0137% | $3.00 | $9,300 | -75.93% | ||
2013-05-21 | Rombotis Spiro George | President and CEO | 200,000 1.4075% | $3.00 | $600,000 | +16.94% | ||
2013-05-21 | McBarron Paul | See Remarks | 12,948 0.092% | $3.03 | $39,213 | +16.94% | ||
2013-05-21 | Sems Lloyd | director | 33,333 0.2346% | $3.00 | $99,999 | +16.94% | ||
2011-12-23 | Rombotis Spiro George | President and CEO | 15,902 0.0288% | $0.49 | $7,871 | +16.00% | ||
2011-09-23 | Sale | MARXE AUSTIN W & GREENHOUSE DAVID M | 10 percent owner | 650,000 1.2397% | $0.51 | $332,930 | +11.43% | |
2011-09-23 | Rombotis Spiro George | President and CEO | 24,100 0.0453% | $0.51 | $12,171 | +11.43% | ||
2011-09-23 | McBarron Paul | See Remarks | 12,000 0.0223% | $0.50 | $6,000 | +11.43% | ||
2011-09-22 | Sale | MARXE AUSTIN W & GREENHOUSE DAVID M | 10 percent owner | 500,000 1.0235% | $0.60 | $302,350 | +0.65% | |
2011-09-22 | Rombotis Spiro George | President and CEO | 5,000 0.01% | $0.59 | $2,965 | +0.65% | ||
2011-09-13 | Rombotis Spiro George | President and CEO | 12,400 – | $0.75 | $9,343 | -23.61% | ||
2011-08-22 | Rombotis Spiro George | President and CEO | 9,232 0.0171% | $0.73 | $6,721 | -21.92% | ||
2011-05-13 | Sale | MARXE AUSTIN W & GREENHOUSE DAVID M | 10 percent owner | 150,000 0.3324% | $1.75 | $263,200 | -61.18% | |
2010-11-30 | Sale | MARXE AUSTIN W & GREENHOUSE DAVID M | 10 percent owner | 142,000 0.3167% | $1.90 | $269,871 | -29.51% | |
2010-11-26 | Sale | MARXE AUSTIN W & GREENHOUSE DAVID M | 10 percent owner | 58,000 0.1253% | $1.90 | $110,310 | -31.75% | |
2010-10-08 | Sale | MARXE AUSTIN W & GREENHOUSE DAVID M | 10 percent owner | 183,982 0.3957% | $1.67 | $307,728 | -17.07% | |
2010-05-04 | Sale | Sosnowski Robert Edward | VP, Marketing & Sales | 10,000 0.0049% | $0.44 | $4,400 | -36.59% |
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