Karyopharm Therapeutics Inc. (KPTI)
Largest Insider Buys in Sector
KPTI Stock Price History Chart
KPTI Stock Performance
About Karyopharm Therapeutics Inc.
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries. Its oral SINE compounds also designed to force nuclear accumulation in the levels of multiple tumor suppressor and growth regulatory proteins. The company was incorporated in 2008 and is headquartered in Newton, Massachusetts.
Insider Activity of Karyopharm Therapeutics Inc.
Over the last 12 months, insiders at Karyopharm Therapeutics Inc. have bought $49,985 and sold $1.82M worth of Karyopharm Therapeutics Inc. stock.
On average, over the past 5 years, insiders at Karyopharm Therapeutics Inc. have bought $195,135 and sold $4.27M worth of stock each year.
Highest buying activity among insiders over the last 12 months: BOHLIN GAREN G (director) — $99,970.
The last purchase of 41,140 shares for transaction amount of $49,985 was made by BOHLIN GAREN G (director) on 2023‑09‑12.
List of Insider Buy and Sell Transactions, Karyopharm Therapeutics Inc.
| 2024-06-07 | Sale | PAKIANATHAN DEEPIKA | director | 2,240 0.0018% | $0.95 | $2,130 | +1.59% | |
| 2024-06-06 | Sale | PAKIANATHAN DEEPIKA | director | 118,452 0.096% | $0.98 | $116,415 | +0.12% | |
| 2024-06-05 | Sale | PAKIANATHAN DEEPIKA | director | 468,044 0.3619% | $0.96 | $448,480 | -2.16% | |
| 2024-06-04 | Sale | Paulson Richard A. | President and CEO | 3,592 0.0033% | $0.99 | $3,556 | +5.01% | |
| 2024-06-04 | Sale | Mason Michael | EVP, CFO & Treasurer | 652 0.0006% | $0.99 | $645 | +5.01% | |
| 2024-06-04 | Sale | PAKIANATHAN DEEPIKA | director | 341,040 0.2976% | $0.95 | $324,704 | +5.01% | |
| 2024-06-03 | Sale | PAKIANATHAN DEEPIKA | director | 360,744 0.3105% | $1.00 | $360,997 | -0.61% | |
| 2024-05-31 | Sale | PAKIANATHAN DEEPIKA | director | 204,394 0.1709% | $0.95 | $194,992 | +1.43% | |
| 2024-05-06 | Sale | Paulson Richard A. | President and CEO | 3,576 0.003% | $1.13 | $4,041 | -11.30% | |
| 2024-04-22 | Sale | Rangwala Reshma | EVP & Chief Medical Officer | 6,789 0.006% | $1.17 | $7,943 | -6.19% | |
| 2024-04-04 | Sale | Paulson Richard A. | President and CEO | 3,563 0.003% | $1.29 | $4,596 | -18.05% | |
| 2024-03-05 | Sale | Paulson Richard A. | President and CEO | 3,573 0.0032% | $1.30 | $4,645 | -10.40% | |
| 2024-03-01 | Sale | Paulson Richard A. | President and CEO | 19,374 0.0172% | $1.20 | $23,249 | -5.88% | |
| 2024-03-01 | Sale | Mason Michael | EVP, CFO & Treasurer | 6,162 0.0055% | $1.20 | $7,394 | -5.88% | |
| 2024-03-01 | Sale | Cheng Sohanya Roshan | EVP & Chief Commercial Officer | 5,109 0.0045% | $1.20 | $6,131 | -5.88% | |
| 2024-03-01 | Sale | Rangwala Reshma | EVP & Chief Medical Officer | 5,969 0.0053% | $1.20 | $7,163 | -5.88% | |
| 2024-03-01 | Sale | Poulton Stuart | EVP, Chief Development Officer | 6,155 0.0055% | $1.20 | $7,386 | -5.88% | |
| 2024-03-01 | Sale | Mano Michael | SVP, General Counsel&Secretary | 3,576 0.0032% | $1.20 | $4,291 | -5.88% | |
| 2024-02-29 | Sale | Paulson Richard A. | President and CEO | 80,470 0.0734% | $1.17 | $94,150 | -3.02% | |
| 2024-02-29 | Sale | Mason Michael | EVP, CFO & Treasurer | 27,687 0.0253% | $1.17 | $32,394 | -3.02% |
Insider Historical Profitability
| Paulson Richard A. | President and CEO | 1150105 0.7172% | $1.00 | 0 | 29 | |
| Mason Michael | EVP, CFO & Treasurer | 398104 0.2156% | $1.00 | 0 | 14 | |
| Cheng Sohanya Roshan | EVP & Chief Commercial Officer | 393509 0.1782% | $1.00 | 0 | 6 | |
| Rangwala Reshma | EVP & Chief Medical Officer | 342931 0.1382% | $1.00 | 0 | 4 | |
| Poulton Stuart | EVP, Chief Development Officer | 329511 0.1365% | $1.00 | 0 | 5 | |
| Mano Michael | SVP, General Counsel&Secretary | 277852 0.1242% | $1.00 | 0 | 4 | |
| BOHLIN GAREN G | director | 45140 0.0394% | $1.00 | 2 | 0 | <0.0001% |
| PAKIANATHAN DEEPIKA | 0 0.0146% | $1.00 | 5 | 7 | +36.66% | |
| Chione Ltd | 10 percent owner | 6000000 5.2386% | $1.00 | 0 | 60 | |
| Plio Ltd | 10 percent owner | 3143473 2.7446% | $1.00 | 0 | 1 | |
| Czernik Marcin | 10 percent owner | 2850517 2.4888% | $1.00 | 0 | 14 | |
| Shacham Sharon | Chief Scientific Officer | 713757 0.6232% | $1.00 | 0 | 64 | |
| Kauffman Michael | director | 713757 0.6232% | $1.00 | 0 | 64 | |
| Frenkel Ran | EVP, Chief Dev. Officer | 168290 0.1469% | $1.00 | 2 | 9 | <0.0001% |
| Shah Jatin | EVP, Chief Medical Officer | 129450 0.113% | $1.00 | 1 | 6 | <0.0001% |
| Mitchener Stephen | SVP, Chief Business Officer | 128313 0.112% | $1.00 | 0 | 3 | |
| Brannelly Paul | SVP, FINANCE & ADMIN, TREAS | 66136 0.0577% | $1.00 | 3 | 0 | +28.23% |
| Renz Justin A | EVP, CFO & Treasurer | 19173 0.0167% | $1.00 | 1 | 1 | <0.0001% |
| DEMAREE JOHN | Chief Commercial Officer | 7500 0.0065% | $1.00 | 1 | 0 | <0.0001% |
| Primiano Christopher Brett | EVP, CBO, GC & Secretary | 4523 0.0039% | $1.00 | 1 | 23 | +28.28% |
| Lewis Tanya | EVP, Chief Reg. Affairs | 4143 0.0036% | $1.00 | 0 | 2 | |
| Greene Barry E | director | 3000 0.0026% | $1.00 | 1 | 0 | <0.0001% |
| Mirza Mansoor Raza | director | 0 0% | $1.00 | 0 | 24 |
Institutional Investor Ownership
| BlackRock | $14.27M | 8.03 | 9.45M | -6.2% | -$942,238.50 | <0.0001 | |
| The Vanguard Group | $12.59M | 7.08 | 8.34M | -4.27% | -$561,353.09 | <0.0001 | |
| Avidity Partners Management Lp | $12.53M | 7.05 | 8.3M | 0% | +$0 | 0.46 | |
| Palo Alto Investors Lp | $7.7M | 4.34 | 5.1M | 0% | +$0 | 0.87 | |
| Eversept Partners LP | $7.57M | 4.26 | 5.02M | New | +$7.57M | 0.57 | |
| Adage Capital Partners Gp L L C | $5.29M | 2.97 | 3.5M | +110.42% | +$2.77M | 0.01 | |
| Citadel Advisors LLC | $4.69M | 2.64 | 3.11M | +0.12% | +$5,541.70 | <0.01 | |
| Marshall Wace | $3.92M | 2.21 | 2.6M | +34.71% | +$1.01M | 0.01 | |
| Geode Capital Management | $3.81M | 2.14 | 2.52M | +5.78% | +$207,916.66 | <0.0001 | |
| State Street | $3.45M | 1.94 | 2.29M | +11.3% | +$350,342.66 | <0.0001 | |
| Goldman Sachs | $2.28M | 1.28 | 1.51M | +16.32% | +$319,620.24 | <0.0001 | |
| C Worldwide Group Holding A S | $2.27M | 1.27 | 1.5M | 0% | +$0 | 0.03 | |
| JPMorgan Chase | $2.08M | 1.17 | 1.38M | +16.63% | +$296,660.80 | <0.0001 | |
| Deutsche Bank | $2M | 1.13 | 1.32M | -0.15% | -$3,066.81 | <0.01 | |
| Gsa Capital Partners Llp | $1.96M | 1.1 | 1.3M | -44.43% | -$1.57M | 0.16 | |
| Millennium Management LLC | $1.79M | 1.01 | 1.19M | -22.71% | -$526,061.27 | <0.01 | |
| Alphacentric Advisors Llc | $1.7M | 0.96 | 1.13M | 0% | +$0 | 1.08 | |
| D. E. Shaw & Co. | $1.45M | 0.82 | 962,825 | +55.99% | +$521,869.68 | <0.01 | |
| Northern Trust | $1.45M | 0.82 | 958,805 | -3.75% | -$56,386.40 | <0.0001 | |
| Renaissance Technologies | $1.37M | 0.77 | 906,800 | -53.84% | -$1.6M | <0.01 | |
| Barclays | $1.35M | 0.76 | 892,815 | -7.96% | -$116,629.94 | <0.01 | |
| Altium Capital Management Lp | $1.12M | 0.63 | 740,000 | 0% | +$0 | 0.52 | |
| Ubs Oconnor Llc | $1.09M | 0.61 | 722,327 | -9.97% | -$120,800.02 | 0.09 | |
| Silverarc Capital Management Llc | $843,284.00 | 0.47 | 558,466 | -0.62% | -$5,268.39 | 0.25 | |
| Macquarie Group | $755,000.00 | 0.43 | 500,000 | +31.58% | +$181,200.00 | <0.01 | |
| Nuveen | $743,471.00 | 0.42 | 492,365 | +8.38% | +$57,475.12 | <0.0001 | |
| BNY Mellon | $735,460.00 | 0.41 | 487,060 | -2.04% | -$15,314.41 | <0.0001 | |
| Birchview Capital Lp | $709,446.00 | 0.4 | 469,832 | 0% | +$0 | 0.04 | |
| Ikarian Capital LLC | $618,126.00 | 0.35 | 409,355 | +2.34% | +$14,126.05 | 0.18 | |
| Los Angeles Capital Management LLC | $585,155.00 | 0.33 | 387,520 | -1.03% | -$6,070.20 | <0.01 | |
| Charles Schwab | $467,963.00 | 0.26 | 309,909 | 0% | +$0 | <0.0001 | |
| Morgan Stanley | $445,128.00 | 0.25 | 294,787 | -65.12% | -$831,048.95 | <0.0001 | |
| Fidelity Investments | $413,450.00 | 0.23 | 273,808 | +2.06% | +$8,338.22 | <0.0001 | |
| UBS | $384,949.00 | 0.22 | 254,933 | -44.24% | -$305,400.66 | <0.0001 | |
| Atom Investors Lp | $369,039.00 | 0.21 | 244,397 | +12.79% | +$41,837.52 | 0.05 | |
| Xtx Topco Ltd | $366,690.00 | 0.21 | 242,841 | +394.36% | +$292,515.76 | 0.02 | |
| Panagora | $347,185.00 | 0.2 | 229,924 | +1.09% | +$3,743.29 | <0.01 | |
| Exchange Traded Concepts, LLC | $321,083.00 | 0.18 | 212,638 | +83.52% | +$146,128.57 | 0.01 | |
| DAFNA Capital Management, LLC | $290,944.00 | 0.16 | 192,678 | 0% | +$0 | 0.07 | |
| AllianceBernstein | $291,143.00 | 0.16 | 192,810 | 0% | +$0 | <0.0001 | |
| Bridgeway Capital Management | $286,145.00 | 0.16 | 189,500 | -34.54% | -$151,000.00 | 0.01 | |
| Jane Street Capital | $259,192.00 | 0.15 | 171,650 | -37.69% | -$156,753.40 | <0.0001 | |
| Bank of America | $238,450.00 | 0.13 | 157,915 | -48.47% | -$224,293.85 | <0.0001 | |
| RhumbLine Advisers | $217,470.00 | 0.12 | 144,028 | +4.29% | +$8,940.20 | <0.0001 | |
| Royal Bank of Canada | $207,000.00 | 0.12 | 137,012 | +79.52% | +$91,694.48 | <0.0001 | |
| Woodline Partners LP | $202,509.00 | 0.11 | 134,112 | +14.9% | +$26,264.92 | <0.01 | |
| AQR Capital | $189,997.00 | 0.11 | 125,826 | -78.96% | -$713,196.18 | <0.0001 | |
| T. Rowe Price | $144,000.00 | 0.08 | 95,091 | +9.16% | +$12,081.40 | <0.0001 | |
| Boothbay Fund Management LLC | $137,547.00 | 0.08 | 91,091 | +11.45% | +$14,126.01 | 0.01 | |
| Susquehanna International Group | $115,664.00 | 0.07 | 76,599 | -2.54% | -$3,015.46 | <0.0001 |